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Development of a fluorescence-based protease biosensor using nanoscale platforms
(University of Missouri--Columbia, 2010)
The development of a protease biosensor utilizing nanomaterials is presented in this dissertation. Peptide substrates and nanomaterial platforms were investigated to increase the sensitivity and response time for the ...
Molecularly imprinted polymer labeled with quantum dots for detection of nitroaromatic explosives
(University of Missouri--Columbia, 2010)
A sensing device for explosive compounds is a fundamental step towards the capability to detect the presence of landmines, improvised explosive devices (IEDs), and other unexploded ordinance. To detect high explosive ...
Development of a fluorescence resonance energy transfer optical nanoscale biosensor based on a liquid-core waveguide platform
(University of Missouri--Columbia, 2007)
In order to produce a more versatile, adaptable, and effective method for detection of biological analytes, a self-contained and robust fluorescent optical biosensor architecture utilizing fluorescence resonance energy ...
Optical characterization of skeletal muscles
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The optical absorption and reduced scattering coefficients of bulk skeleton muscle were measured by fitting the diffusion model to spatially resolved ...
Electrospinning lecithin-polycaprolactone scaffolds with gold nanoparticles for osteoarthritis prevention
(University of Missouri--Columbia, 2018)
The human body has articular cartilage covering the ends of the bones to act as a shock absorber and aid in movement. In a disease state, this articular cartilage breaks down causing pain, swelling, and stiffness. With ...
A fiber-optic confocal scanner for scattering tissue
(University of Missouri--Columbia, 2009)
on the micrometer scale. While commercial confocal microscopes are readily available, they may not be suitable for examining tissues in vivo or able to accommodate large samples. The presented work offers a prototype device based on the principle of confocal...
Flourescent molecular rotors as mechanosensors in biofluids
(University of Missouri--Columbia, 2005)
Many disease states have associated blood viscosity changes. Molecular rotors, fluorescent molecules with viscosity sensitive quantum yields, have recently been investigated as a new method for biofluid viscosity measurement. ...
Automated detection of amperometric spikes resulting from quantal exocytosis and estimation of spike and pre-spike foot signal parameters
(University of Missouri--Columbia, 2018)
Electrochemical microelectrodes can detect single-vesicle release events as "spikes" of amperometric current. We developed a template based "matched-filter" approach that performs least squares fit of a library of templates ...
Novel methods for quantifying lung and cardiac diseases with magnetic resonance imaging
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 5/1/2024] Magnetic Resonance Imaging (MRI) is an advanced imaging technique that has transformed the field of medical diagnosis and treatment. In the field of lung and cardiac imaging, MRI boasts the ...
Design and characterization of a hand-held, waveguide-mediated, optoacoustic imaging probe for analyzing burn wounds
(University of Missouri--Columbia, 2018)
Clinicians correctly diagnose only [about]66% of burn wounds, which may be in part due to the qualitative methods commonly employed for burn assessment. This often results in over diagnoses, which may lead to unnecessary ...
Multi-scale self-assembly of nanoenergetic materials utilizing functionalized graphene
(University of Missouri--Columbia, 2020)
The work described here-in focuses on the synthesis and characterization of novel nanoenergetic materials and is driven by overcoming the disadvantages of traditional nanoenergetic composites, improving the energetic ...
Imaging structurual and mechanical properties in cardiovascular tissue using optical polarization tractography
(University of Missouri--Columbia, 2022)
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the US. Every 36 seconds, one person dies from CVD [1]. Structural deficiencies and secondary changes induced by either abnormal functioning ...
Creating a zero-waste soy processing system and developing vitamin B12 fortified non-GMO high oleic soy-based products using encapsulation technology
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 5/1/2024] High-oleic (HO) soybeans contain approximately 72-75 percent of oleic acid and 20 percent or less saturated fatty acids as compared to the traditional soybean variety. High levels of oleic acid ...